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John Pernow Selected Research

Diabetes Mellitus

10/2020Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD.
1/2016The Emerging Role of Arginase in Endothelial Dysfunction in Diabetes.
2/2014Increased levels of circulating arginase I in overweight compared to normal weight adolescents.
1/2014Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus.
6/2013Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
12/2012Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus.
10/2012New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus.

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John Pernow Research Topics

Disease

22Type 2 Diabetes Mellitus (MODY)
08/2023 - 02/2005
21Ischemia
11/2022 - 06/2002
20Reperfusion Injury
08/2023 - 10/2002
19Infarction (Infarctions)
01/2022 - 06/2007
17Myocardial Infarction
11/2023 - 01/2010
16Cardiovascular Diseases (Cardiovascular Disease)
12/2023 - 08/2003
15Atherosclerosis
01/2023 - 01/2002
14Coronary Artery Disease (Coronary Atherosclerosis)
02/2022 - 10/2004
13ST Elevation Myocardial Infarction
01/2023 - 04/2010
11Myocardial Ischemia (Ischemic Heart Diseases)
08/2023 - 11/2002
7Thrombosis (Thrombus)
11/2023 - 04/2012
7Diabetes Mellitus
10/2020 - 10/2012
5Hypoxia (Hypoxemia)
01/2023 - 05/2011
5Heart Failure
12/2020 - 01/2013
5Hypertension (High Blood Pressure)
01/2020 - 02/2005
5Insulin Resistance
08/2011 - 03/2006
3Vascular Diseases (Vascular Disease)
01/2022 - 09/2010
2Neoplasms (Cancer)
10/2023 - 05/2011
2Human Influenza (Influenza)
01/2023 - 11/2021
2Non-ST Elevated Myocardial Infarction
01/2023 - 09/2017
2Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
01/2023 - 11/2022
2COVID-19
11/2022 - 12/2021
2Hypercholesterolemia
11/2022 - 01/2020
2Cardiomyopathies (Cardiomyopathy)
12/2021 - 07/2018
2Chronic Obstructive Pulmonary Disease (COPD)
12/2021 - 12/2020
2Coronary Disease (Coronary Heart Disease)
11/2021 - 02/2005
2Infections
05/2021 - 03/2014
2Acute Coronary Syndrome
01/2021 - 01/2021
2Obesity
01/2020 - 02/2014
2Heart Arrest (Cardiac Arrest)
01/2020 - 10/2014
2Atherosclerotic Plaque (Atheroma)
01/2020 - 03/2014
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2017 - 10/2003
2Inflammation (Inflammations)
09/2009 - 05/2003
1Prediabetic State (Prediabetes)
10/2023
1Metabolic Diseases (Metabolic Disease)
01/2023

Drug/Important Bio-Agent (IBA)

27ArginaseIBA
01/2023 - 01/2010
16Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2023 - 10/2002
13Endothelin-1 (Endothelin 1)IBA
01/2020 - 01/2002
10Arginine (L-Arginine)FDA Link
01/2022 - 12/2003
8Nitric Oxide Synthase (NO Synthase)IBA
08/2018 - 05/2004
7Proteins (Proteins, Gene)FDA Link
11/2021 - 06/2002
6Endothelins (Endothelin)IBA
08/2016 - 05/2004
6Endothelin Receptors (Endothelin Receptor)IBA
12/2015 - 04/2002
5salicylhydroxamic acid (SHAM)IBA
11/2022 - 08/2007
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2023 - 08/2018
4LipidsIBA
11/2022 - 01/2009
4CytokinesIBA
02/2022 - 04/2012
4Biomarkers (Surrogate Marker)IBA
12/2021 - 05/2003
4omega-N-Methylarginine (NG Monomethyl L Arginine)IBA
01/2017 - 05/2004
4Acetylcholine (Acetylcholine Chloride)FDA Link
11/2016 - 03/2002
4Vasoconstrictor AgentsIBA
12/2015 - 01/2002
4C-Reactive ProteinIBA
02/2014 - 05/2003
4Bosentan (Tracleer)FDA Link
09/2013 - 05/2004
4cyclo(Trp-Asp-Pro-Val-Leu)IBA
01/2008 - 03/2002
3Influenza Vaccines (Influenza Vaccine)FDA Link
11/2023 - 11/2021
3Glucose (Dextrose)FDA LinkGeneric
10/2023 - 08/2011
3Oxygen (Dioxygen)IBA
11/2022 - 01/2017
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2022 - 08/2007
3Messenger RNA (mRNA)IBA
05/2021 - 03/2014
3erucylphosphocholineIBA
09/2013 - 09/2010
3Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
09/2009 - 06/2007
2Soluble Guanylyl CyclaseIBA
08/2023 - 01/2018
2Guanosine Monophosphate (5' Guanylic Acid)IBA
08/2023 - 01/2023
2LDL CholesterolIBA
01/2023 - 11/2022
2oxidized low density lipoproteinIBA
01/2023 - 11/2022
2MicroRNAs (MicroRNA)IBA
01/2023 - 10/2020
2AZD5718IBA
10/2022 - 09/2020
2Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
01/2022 - 06/2002
2Adenosine Triphosphate (ATP)IBA
01/2022 - 07/2013
2TicagrelorIBA
01/2021 - 01/2021
2Streptozocin (Streptozotocin)FDA Link
10/2020 - 01/2017
2BuffersIBA
01/2020 - 05/2004
2Peroxynitrous Acid (Peroxynitrite)IBA
01/2020 - 01/2014
2EnzymesIBA
01/2020 - 02/2014
2hydroxyfasudilIBA
01/2017 - 01/2014
2OrnithineIBA
11/2016 - 01/2016
2CitrullineIBA
11/2016 - 01/2016
2Simvastatin (Zocor)FDA LinkGeneric
12/2014 - 01/2009
2Peptides (Polypeptides)IBA
09/2013 - 03/2006
2mitochondrial K(ATP) channelIBA
07/2013 - 02/2005
2Interleukin-6 (Interleukin 6)IBA
10/2012 - 05/2003
2Glucagon-Like Peptide 1 (GLP 1)IBA
10/2009 - 02/2005
2Ezetimibe (Zetia)FDA Link
09/2009 - 01/2009
2AdiponectinIBA
08/2009 - 04/2008
2Endothelin A ReceptorIBA
07/2008 - 01/2008
2CholesterolIBA
07/2008 - 06/2007
2BQ 788IBA
03/2007 - 03/2006
1Lipoprotein(a)IBA
12/2023
1Untranslated RNA (Noncoding RNA)IBA
11/2023
1Blood Glucose (Blood Sugar)IBA
10/2023
1Metformin (Glucophage)FDA LinkGeneric
10/2023
1Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
08/2023
1VaccinesIBA
01/2023

Therapy/Procedure

8Percutaneous Coronary Intervention
10/2022 - 04/2010
6Therapeutics
10/2023 - 03/2016
5Stents
11/2023 - 04/2012
4Intra-Arterial Infusions
01/2014 - 03/2002
2Resuscitation
01/2020 - 10/2014
2Ischemic Postconditioning
03/2013 - 04/2012
1Hyperbaric Oxygenation
11/2022